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Mandible / maxilla – Malignant tumors: ameloblastic fibrosarcoma. A case of an ameloblastic fibrosarcoma in the mandible is described. The primary tumor was seen in a 5-year-old child. In spite of repeated surgical. Introduction. Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor. It can arise de novo, however one-third of cases may arise from a recurrent.

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Case report and review of the literature.

Journal of Oral Pathology and Medicine. Nil Conflict of Interest: AF is the main differential diagnosis of Sarcpma. Those lesions arising from an AF tend to occur in patients aged approximately a decade older than those arising de novo [ 10 ].

Adjuvant chemotherapy has also been used with moderate success [ 17 ], although no specific chemotherapy protocols have been established yet. A case report with long-term follow-up. Report of 2 chemosensitive pediatric cases. Here, we report a case of AFS in a year-old man in the maxilla, which was regarded as an uncommon location for this tumor. Histologically, it consisted of a mixed epithelial-mesenchymal odontogenic neoplasm composed of benign islands of well-differentiated ameloblastic epithelium within a malignant fibrous stroma consisting of spindle cells or fibroblasts with a brisk mitotic activity.

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After 2 years follow up, no evidence of recurrence was noted. Her ameloblasitc at presentation was 22 years old, a little younger than the mean age of presentation, but still in the third decade of life, like most patients from previous reports. Histopathologic examination of the whole specimen confirmed the diagnosis of AFS.

Odontogenic Tumors and Allied Lesions.

We also emphasize on comprehensive clinical, radiographic, and histopathologic evaluation of such patients rather than immunohistochemical staining to firo an accurate diagnosis.

Ameloblastic fibrosarcoma AFS is a rare malignant odontogenic tumor. Radiographically, AFS usually appears as an expansile destructive radiolucency with ill-defined margins.

Ameloblastic fibrosarcoma AFS is a rare mixed odontogenic tumor composed of benign epithelial and malignant ectomesenchymal components.

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Extraoral evaluation revealed a gross swelling over the left mandible Figure 1. Published online Mar Rare mixed odontogenic tumor that consists of a benign ameloblastic epithelium and a malignant mesenchymal stroma Thought to be malignant counterpart ameloblastoc ameloblastic fibroma.

Only 2 cases of metastasis have been reported [ 1516 ]. Ameloblastic fibrosarcoma AFS is a malignant odontogenic tumor characteristically composed of a benign epithelium and a malignant mesenchymal component [ 2 ]. Journal of Cranio-Maxillo-Facial Surgery. Open in a separate window. Rare, More common in males 1. Treatment of choice is wide surgical excision, with long-term follow-up.

Ameloblastic fibrosarcoma: a rare malignant odontogenic tumor.

Radiologically, AFS presents as a radiolucent mass with ill-defined borders. Accessed December 31st, Introduction Odontogenic tumors and tumor-like lesions constitute a rare group of heterogeneous diseases that range from nonneoplastic tissue proliferations to malignant tumors with amelovlastic potential. Both neoplasms have a biphasic nature; however, AF has no malignant maeloblastic, unlike AFS in which the mesenchymal component presents marked cellularity, nuclear pleomorphism, hyperchromatism, and a moderate to high number of mitotic figures.

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A biopsy of the mass was performed.

Please review our privacy policy. Recently, some authors have suggested a panel of biomarkers associated with cell proliferation Ki67, PCNA, and c-KIT and apoptosis Bcl2 to overcome difficulties in the diagnosis of low-grade tumors and evaluate the growth potential in the mesenchymal component without considering clinical and radiographic findings.

Ameloblastic Fibrosarcoma of the Mandible: A Case Report and Brief Review of the Literature

Maryam Khalili 1 and Pouyan Amini Shakib 2. Received Jan 11; Accepted Mar 2. No evidence of regional lymphadenopathy or distant metastasis was found and a segmental resection of the maxilla along with wide excision of the surrounding soft tissues was performed.